Does Lingzhi Help Support Antioxidant Activity and Healthy Aging?

UV is a primary environmental factor implicated in skin aging; it causes coarse wrinkling, dryness, and laxity (Kong et al. 2018). UVB irradiation stimulates MMP-1 secretion and reduces the synthesis of collagen and elastin, which can accelerate skin senescence (Hwang et al. 2018). The extract of Lingzhi cracked spores / Ganoderma lucidum can inhibit UVB-induced MMP-1 expression and increased procollagen expression by inhibiting ERK pathways (Lee et al. 2018). GLPs can inhibit MMP-1 protein expression, promote C-telopeptides of type I collagen protein, and inhibit ROS production in fibroblasts following UVB treatment (Zeng et al. 2017).

The long-term presence of free radicals and ROS accelerates aging and numerous age-associated illnesses (Bishop et al. 2015). Therefore, studies on scavenging free radicals and ROS are particularly important in anti-aging research.

( Reference: https://www.jidonline.org/article/S0022-202X(18)31356-3/fulltext )

The antioxidant properties of crude proteins obtained from the mycelium and fruiting bodies of Ganoderma lucidum were studied. It was found that protein from both the mycelia and fruit body exhibited antioxidant capacity. The mycelial protein extract showed better scavenging activities than those shown by fruiting body protein extract, in terms of both 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) radical- and 2,2-diphenylpicrylhydrazyl radical (DPPH•) radical-scavenging abilities (Sa-Ard et al. 2015). Oxidative stress markers were measured by using the comet assay to measure ROS generation. Furthermore, the ethanol extract of Lingzhi cracked spores could significantly reduce H2O2-induced ROS production compared to that in the positive control (Lee et al. 2016).

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