Is Lingzhi Anti-inflammatory? – HQ Lingzhi Singapore

Is Lingzhi Anti-inflammatory?

Lingzhi Cracked Spores has been an important functional ingredient in many salve formulations due to its anti-aging, anti-melanogenesis, and skin barrier-enhancing properties. Inflammation is a normal physiological response to an infection or injury, which is part of host defense and tissue healing. In the inflammatory environment of the body, elevated levels of TNF-α, IFN-γ, and IL-4 can further accelerate the inflammatory response in the dermis and destroy epidermal barrier function. GLPss58, a sulfated form of a polysaccharide from the fruiting body of Lingzhi, can inhibit the binding of L-selectin with the receptor, activate the complement systems, and block the binding of TNF-α and INF-γ to their antibodies. GLPss58 could inhibit all the L-selectin-, complement-, and cytokine-mediated inflammation pathways. In addition, GLPs can prevent inflammation, maintain intestinal homeostasis, and regulated the intestinal immunological barrier functions in mice by markedly suppressing the secretions of TNF-α, IL-1β, IL-6, and IL-4. The anti-inflammatory effect of GLPs plays an important role in clinic for sensitive skin.

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